Publications co-authored by the 2 or more HEPRO-2 partners (2012-2016): PDF

Recent publications 10/2015-05/2016: PDF

Selected list of publications by the internaitional partners (2012-2015): PDF


Selected list of publications by the HEPRO-1 and HEPRO-2 partners (2012-2015) :

Partner P1a - VUB-Toxicology (IVTD)

  1. Snykers S, De Kock J, Vanhaecke T, Rogiers V. (2007) Differentiation of neonatal rat epithelial cells from biliary origin into immature hepatic cells by sequential exposure to hepatogenic cytokines and growth factors reflecting liver development. Toxicology In vitro. 2007; 21(7):1325-1331.
  2. Snykers S, Vanhaecke T, De Becker A, Papeleu P, Vinken M, Van Riet I, Rogiers V. (2007) Chromatin remodelling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow. BMC Developmental Biology. BMC Dev Biol. 2007 Apr 2;7:24.
  3. Snykers S, Rogiers V, Vinken M, Vanhaecke T. (2007) Differential role of epigenetic modulators in malignant and normal stem cells: a novel tool in preclinical in vitro toxicology and clinical therapy. Archives of Toxicology 81(8):533-544.
  4. Snykers S, De Kock J, Rogiers V, Vanhaecke T. In vitro differentiation of embryonic and adult stem cells into hepatocytes: state of the art. Stem Cells. 2008; 27(3):577-605.
  5. De Kock J, Vanhaecke T, Rogiers V, Snykers S. (2008) Chromatin remodelling, a novel strategy to expedite the hepatic differentiation of adult bone marrow stem cells in vitro. AATEX, 14:605-611.
  6. De Kock J, Vanhaecke T, Biernaskie J, Rogiers V, Snykers S (2009) Characterization and hepatic differentiation of skin-derived precursors from adult foreskin by sequential exposure to hepatogenic cytokines and growth factors reflecting liver development. Toxicology In vitro, 23: 1522-1527.
  7. Snykers S, Henkens T, De Rop E, Vinken M, Fraczek J, De Kock J, De Prins J, Geerts A, Rogiers V and Vanhaecke T. (2009) Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation, and stem cell reprogrammation.  J Hepatol. 2009 Jul;51(1):187-211. Epub 2009 Apr 2.
  8. De Kock J, Ceelen L, De Spiegelaere W, Casteleyn C, Claes P, Vanhaecke T and Rogiers V.  Simple and quick method for whole-liver decellularization: a novel in vitro three-dimensional bioengineering tool? Arch Toxicol. 2011, 85(6): 607-612.
  9. Bolleyn J, De Kock J, Mertens H, Fraczek F, Vinken M, Govaere O, Roskams T, Rogiers V and Vanhaecke T. (2012) Liver-Specific miR-122 does Not Affect mRNA Levels of Cytochrome P450 Enzymes and Nuclear Receptors in Primary Rat Hepatocyte Cultures. ALTEX. 29: 165-172.
  10. De Kock J, Najar M, Bolleyn J, Al Battah F, Rodrigues RM, Buyl K, Raicevic G, Govaere O, Branson S, Meganathan K, Gaspar JA, Roskams T, Sachinidis A, Lagneaux L, Vanhaecke T, Rogiers V. Mesoderm-Derived Stem Cells: The Link Between the Transcriptome and Their Differentiation Potential. Stem Cells Dev. 2012 Dec 10;21(18):3309-23.
  11. Rodrigues RM, De Kock J, Branson S, Vinken M, Meganathan K, Chaudhari U, Sachinidis A, Govaere O, Roskams T, De Boe V, Vanhaecke T, Rogiers V. Human Skin-Derived Stem Cells as a Novel Cell Source for In Vitro Hepatotoxicity Screening of Pharmaceuticals. Stem Cells Dev. 2013 Sep 21. [Epub ahead of print]
  12. C Buyl K, De Kock J, Najar M, Lagneaux L, Branson S, Rogiers V, Vanhaecke T. Characterization of hepatic markers in human Wharton's Jelly-derived mesenchymal stem cells. Toxicol In Vitro. 2014 Feb;28(1):113-9. doi: 10.1016/j.tiv.2013.06.014. Epub 2013 Jun 29.
  13. Rodrigues RM, De Kock J, Branson S, Vinken M, Meganathan K, Chaudhari U, Sachinidis A, Govaere O, Roskams T, De Boe V, Vanhaecke T, Rogiers V. Human Skin-Derived Stem Cells as a Novel Cell Source for In Vitro Hepatotoxicity Screening of Pharmaceuticals. Stem Cells Dev. Stem Cells Dev. 2014 Jan 1;23(1):44-55 Epub 2013 Sep 21.
  14. Najar M, Rodrigues RM, Buyl K, Branson S, Vanhaecke T, Lagneaux L, Rogiers V, De Kock J. Proliferative and phenotypical characteristics of human adipose tissue-derived stem cells: comparison of Ficoll gradient centrifugation and red blood cell lysis buffer treatment purification methods. Cytotherapy. 2014 Sep;16(9):1220-8. Epub 2014 Jul 22.
  15. Ramboer E, De Craene B, De Kock J, Vanhaecke T, Berx G, Rogiers V, Vinken M. Strategies for immortalization of primary hepatocytes. J Hepatol. 2014 Oct;61(4):925-43. Epub 2014 Jun 6.
  16. De Kock J, Meuleman P, Raicevic G, Rodrigues RM, Branson S, Meganathan K, De Boe V, Sachinidis A, Leroux-Roels G, Vanhaecke T, Lagneaux L, Rogiers V, Najar M. Human skin-derived precursor cells are poorly immunogenic and modulate the allogeneic immune response.  Stem Cells. 2014 Aug;32(8):2215-28.
  17. Rodrigues RM, Sachinidis A, De Boe V, Rogiers V, Vanhaecke T, De Kock J. Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors. Toxicol In Vitro. 2015 Sep;29(6):1231-9. Epub 2014 Oct 24.
  18. Buyl K, Vanhaecke T, Desmae T, Lagneaux L, Rogiers V, Najar M, De Kock J. Evaluation of a new standardized enzymatic isolation protocol for human umbilical cord-derived stem cells. Toxicol In Vitro. 2015 Sep;29(6):1254-62. Epub 2014 Dec 23.
  19. Ramboer E, De Craene B, De Kock J, Vanhaecke T, Berx G, Rogiers V, Vinken M. Strategies for immortalization of primary hepatocytes. J Hepatol. 2014 Oct;61(4):925-43. doi: 10.1016/j.jhep.2014.05.046. Epub 2014 Jun 6.
  20. Rodrigues RM, Branson S, De Boe V, Sachinidis A, Rogiers V, De Kock J, Vanhaecke T. In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells. Arch Toxicol. 2015 Feb 26. [Epub ahead of print] 

Partner P1b - VUB-Liver Cell Biology (LIVR)

  1. A Geerts. The simple truth is seldom true and never simple: dual role for p75(NTR) in transdifferentation and cell death of hepatic stellate cells. Hepatology. 2007 Aug;46(2):600-1.
  2. Leclercq IA, Da Silva Morais A, Schroyen B, Van Hul N, Geerts A. Mechanisms and consequences of insulin resistance in liver cells. J Hepatol 2007;Jul;47(1):142-56. Epub 2007 Apr 16.
  3. Dollé L, Best J, Mei J, Battah FA, Reynaert H, , van Grunsven LA, Geerts A. The quest for liver progenitor cells: A practical point of view. J Hepatol. 2010 Jan;52(1):117-29. Epub 2009 Oct 28. 
  4. Mannaerts I., Nuytten NR, Rogiers V, Vanderkerken K, van Grunsven LA and Geerts A. Chronic administration of sodium valproate inhibits activation of mouse hepatic stellate cells in vitro and in vivo. Hepatology, 2010 Feb;51(2):603-14
  5. Thoen LF, Guimarães EL, Dollé L, Mannaerts I, Najimi M, Sokal E, van Grunsven LA.  A role for autophagy during hepatic stellate cell activation. J Hepatol. 2011 Dec;55(6):1353-60. Epub 2011 Jul 29
  6. Dollé L, Streetz KL, van Grunsven LA. Sharpen your look on liver progenitor cells. Hepatology. 2012 Jan;55(1):319-21.
  7. Dollé L, Best J, Empsen C, Mei J, Van Rossen E, Roelandt P, Snykers S, Najimi M, Al Battah F, Theise ND, Streetz K, Sokal E, Leclercq IA, Verfaillie C, Rogiers V, Geerts A, van Grunsven LA. Successful isolation of liver progenitor cells by aldehyde dehydrogenase activity in naïve mice. Hepatology. 2012 Feb;55(2):540-52.
  8. Theise ND, Dollé L, Kuwahara R. Low hepatocyte repopulation from stem cells: a matter of hepatobiliary linkage not massive production. Gastroenterology. 2013 Jul;145(1):253-4. Epub 2013 May 31.
  9. Coombes JD, Swiderska-Syn M, Dollé L, Reid D, Eksteen B, Claridge L, Briones-Orta MA, Shetty S, Oo YH, Riva A, Chokshi S, Papa S, Mi Z, Kuo PC, Williams R, Canbay A, Adams DH, Diehl AM, van Grunsven LA, Choi SS, Syn WK. Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice. Gut. 2015 Jul;64(7):1120-31. Epub 2014 Jun 5.
  10. Bogaerts E, Heindryckx F, Vandewynckel YP, Van Grunsven LA, Van Vlierberghe H. The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours. Int J Oncol. 2014 Apr;44(4):1015-22. doi: 10.3892/ijo.2014.2286. Epub 2014 Feb 3
  11. Rodrigo-Torres D, Affò S, Coll M, Morales-Ibanez O, Millán C, Blaya D, Alvarez-Guaita A, Rentero C, Lozano JJ, Maestro MA, Solar M, Arroyo V, Caballería J, van Grunsven LA, Enrich C, Ginès P, Bataller R, Sancho-Bru P. The biliary epithelium gives rise to liver progenitor cells. Hepatology. 2014 Oct;60(4):1367-77. doi: 10.1002/hep.27078. Epub 2014 Aug 21.
  12. Paganelli M, Nyabi O, Sid B, Evraerts J, El Malmi I, Heremans Y, Dollé L, Benton C, Calderon PB, van Grunsven L, Heimberg H, Campard D, Sokal E, Najimi M.Downregulation of Sox9 Expression Associates with Hepatogenic Differentiation of Human Liver Mesenchymal Stem/Progenitor Cells. Stem Cells Dev. 2014 Jun 15;23(12):1377-91. doi: 10.1089/scd.2013.0169. Epub 2014 May 5.
  13. Gevaert E, Dollé L, Billiet T, Dubruel P, van Grunsven L, van Apeldoorn A, Cornelissen R. High throughput micro-well generation of hepatocyte micro-aggregates for tissue engineering. PLoS One. 2014 Aug 18;9(8):e105171. doi: 10.1371/journal.pone.0105171. eCollection 2014.
  14. Dollé L, Theise ND, Schmelzer E, Boulter L, Gires O, van Grunsven LA. EpCAM and the biology of hepatic stem/progenitor cells. Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15;308(4):G233-G250. doi: 10.1152/ajpgi.00069.2014. Epub 2014 Dec 4. Review.
  15. Dollé L, Boulter L, Leclercq IA, van Grunsven LA. Next generation of ALDH substrates and their potential to study maturational lineage biology in stem and progenitor cells. Am J Physiol Gastrointest Liver Physiol. 2015 Apr 1;308(7):G573-8. Epub 2015 Feb 5
  16. Dollé L, Gao B. Pharmacological Chaperone Therapies: Can Aldehyde Dehydrogenase Activator Make Us Healthier? J Hepatol. 2015 Jun;62(6):1228-30. Epub 2015 Feb 12. 
  17. Best J, Manka P, Syn WK, Dollé L, van Grunsven LA, Canbay A. Role of liver progenitors in liver regeneration. Hepatobiliary Surg Nutr. 2015 Feb;4(1):48-58.
  18. Bogaerts E, Heindryckx F, Devisscher L, Paridaens A, Vandewynckel YP, Van den Bussche A, Verhelst X, Libbrecht L, van Grunsven LA, Geerts A, Van Vlierberghe H. Time-dependent effect of hypoxia on tumor progression and liver progenitor cell markers in primary liver tumors. PLoS One. 2015 Mar 20;10(3):e0119555. doi: 10.1371/journal.pone.0119555. eCollection 2015.

Partner P2 - UGent-Vaccinology (CEVAC) - to be updated

  1. Vanwolleghem T, Libbrecht L, Hansen BE, Desombere I, Roskams T, Meuleman P, Leroux-Roels G.  Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID Mice. J Hepatol. 2010 Sep;53(3):468-76. Epub 2010 May 31.
  2. Meuleman P, Bukh J, Farhoudi A, Desombere I, Vanwolleghem T, Alter H, Purcell R, Leroux-Roels G. In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus. Hepatology, 2011, Mar;53(3):755-62
  3. Meuleman P, Catanese MT, Verhoye L, Desombere I, Farhoudi A, Jones CT, Sheahan T, Grzyb K, Cortese R, Rice CM, Leroux-Roels G, Nicosia A. A Human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo. Hepatology. 2012 Feb;55(2):364-72. Epub 2011 Dec 16.
  4. Lacek K, Vercauteren K, Grzyb K, Naddeo M, Verhoye L, Slowikowski MP, Fafi-Kremer S, Patel AH, Baumert TF, Folgori A, Leroux-Roels G, Cortese R, Meuleman P, Nicosia A. Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice.  J Hepatol. 2012 Jul;57(1):17-23. Epub 2012 Mar 10.
  5. Anggakusuma, Colpitts CC, Schang LM, Rachmawati H, Frentzen A, Pfaender S, Behrendt P, Brown RJ, Bankwitz D, Steinmann J, Ott M, Meuleman P, Rice CM, Ploss A, Pietschmann T, Steinmann E. Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells. Gut. 2013 Jul 31. [Epub ahead of print]
  6. Foquet L, Hermsen CC, van Gemert GJ, Libbrecht L, Sauerwein R, Meuleman P, Leroux-Roels G.  Molecular detection and quantification of Plasmodium falciparum-infected human hepatocytes in chimeric immune-deficient mice. Malaria Journal, 2013 Nov 24;12(1):430. [Epub ahead of print]
  7. Foquet L, Hermsen CC, van Gemert GJ, Van Braeckel E, Weening KE, Sauerwein R, Meuleman P, Leroux-Roels G. Vaccine-induced monoclonal antibodies prevent in vivo Plasmodium falciparum infection. J Clin Invest. 2014 Jan;124(1):140-4.
  8. Vercauteren K, Van Den Eede N, Mesalam AA, Belouzard S, Catanese MT, Bankwitz D, Wong-Staal F, Cortese R, Dubuisson J, Rice CM, Pietschmann T, Leroux-Roels G, Nicosia A, Meuleman P. Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents. Hepatology. 2014 Nov;60(5):1508-18. doi: 10.1002/hep.27196. Epub 2014 Jul 30.
  9. Mailly L, Xiao F, Lupberger J, Wilson GK, Aubert P, Duong FH, Calabrese D, Leboeuf C, Fofana I, Thumann C, Bandiera S, Lütgehetmann M, Volz T, Davis C, Harris HJ, Mee CJ, Girardi E, Chane-Woon-Ming B, Ericsson M, Fletcher N, Bartenschlager R, Pessaux P, Vercauteren K, Meuleman P, Villa P, Kaderali L, Pfeffer S, Heim MH, Neunlist M, Zeisel MB, Dandri M, McKeating JA, Robinet E, Baumert TF. Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody. Nat Biotechnol. 2015 May;33(5):549-54. doi: 10.1038/nbt.3179. Epub 2015 Mar 23.


Partner P3a - UCL-Gastroenterology (GAEN) - to be updated

  1. Van Hul N, Abarca-Quinones J, Sempoux C, Horsmans Y, Leclercq IA. Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury. Hepatology. 2009 May;49(5):1625-35.
  2. Van Hul N, Lanthier N, Español Suñer R, Abarca Quinones J, van Rooijen N, Leclercq I. Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury.  Am J Pathol. 2011 Oct;179(4):1839-50. Epub 2011 Aug 18.
  3. Dusabineza AC, Van Hul NK, Abarca-Quinones J, Starkel P, Najimi M, Leclercq IA. Participation of liver progenitor cells in liver regeneration: lack of evidence in the AAF/PH rat model.. Lab Invest. 2012 Jan;92(1):72-81. Epub 2011 Sep 12.
  4. Español-Suñer R, Carpentier R, Van Hul N, Legry V, Achouri Y, Cordi S, Jacquemin P, Lemaigre F, Leclercq IA. Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice. Gastroenterology. 2012 Dec;143(6):1564-1575. Epub 2012 Aug 21.
  5. N Charette, C De Saeger, Y Horsmans, I Leclercq, and P Stärkel. Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms. Cell Death Dis. 2013 January; 4(1): e471.
  6. I Leclercq. Non-alcoholic steatohepatitis and the diabetic patient. Louvain Medical, 2013;132:107-9.
  7. Lebrun V, Molendi-Coste O, Lanthier N, Sempoux C, Cani PD, van Rooijen N, Stärkel P, Horsmans Y, Leclercq IA. Impact of PPARα induction on glucose homesostasis in alcohol-fed mice. Clin Sci (Lond). 2013 Dec;125(11):501-11.
  8. Schaap FG, Leclercq IA, Jansen PL, Olde Damink SW. Prometheus' little helper, a novel role for fibroblast growth factor 15 in compensatory liver growth. J Hepatol. 2013 Nov;59(5):1121-3. doi: 10.1016/j.jhep.2013.07.013. Epub 2013 Jul 16.
  9. Legry V, Van Rooyen DM, Lambert B, Sempoux C, Poekes L, Español-Suñer R, Molendi-Coste O, Horsmans Y, Farrell GC, Leclercq IA. Endoplasmic reticulum stress does not contribute to steatohepatitis in obese and insulin-resistant high-fat-diet-fed foz/foz mice. Clin Sci (Lond). 2014 Oct;127(7):507-18.


Partner P3b - UCL-Liver and Pancreas Development (LPAD) - to be updated

  1. Si-Tayeb K., Lemaigre F.P. and Duncan SA. (2010) Organogenesis and development of the liver. Developmental Cell 18: 175-189.
  2. Antoniou A., Raynaud P., Cordi S., Zong Y., Tronche F., Stanger B., Jacquemin P., Pierreux C., Clotman C., Lemaigre F.P. (2009) Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9. Gastroenterology 136: 2325-2333.
  3. Carpentier R, Suñer RE, van Hul N, Kopp JL, Beaudry JB, Cordi S, Antoniou A, Raynaud P, Lepreux S, Jacquemin P, Leclercq IA, Sander M, Lemaigre FP. Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells. Gastroenterology, 2011 Oct;141(4):1432-8, 1438.e1-4. Epub 2011 Jun 25.
  4. Laudadio I, Manfroid I, Achouri Y, Schmidt D, Wilson MD, Cordi S, Thorrez L, Knoops L, Jacquemin P, Schuit F, Pierreux CE, Odom DT, Peers B, Lemaigre FP. A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation. Gastroenterology. 2012 Jan;142(1):119-29. Epub 2011 Sep 12.
  5. Roelandt P, Antoniou A, Libbrecht L, Van Steenbergen W, Laleman W, Verslype C, Van der Merwe S, Nevens F, De Vos R, Fischer E, Pontoglio M, Lemaigre F, Cassiman D. HNF1B deficiency causes ciliary defects in human cholangiocytes. Hepatology. 56, 1178-1181, 2012. (IF 2012= 12,00)
  6. Lemaigre F. [Lineage fate decisions in normal and regenerating liver] Le développement des lignages hépatiques dans le foie normal et durant la régénération. Med Sci (Paris). 2012 Nov;28(11):958-62.
  7. Lemaigre FP. Hepatocytes as a source of cholangiocytes in injured liver. Hepatology. Hepatology. 2014 Feb;59(2):726-8. Epub 2013 Dec 18.
  8. Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, and Sosa-Pineda B. Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47.


Partner P4 - KULeuven- Morphology and Molecular Pathology - to be updated

  1. Fabris L., Cadamuro M., Libbrecht L., Raynaud P., Spirlì C., Fiorotto R., Okolicsanyi L., Lemaigre F., Strazzabosco M. and Roskams T. (2008) Epithelial expression of angiogenic growth factors modulate arterial vasculogenesis in human liver development. Hepatology 47(2): 719-728.
  2. Komuta M, Spee B, Vander Borght S, De Vos R, Verslype C, Aerts R, Yano H, Suzuki T, Matsuda M, Fujii H, Desmet VJ, Kojiro M, Roskams T. Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin. Hepatology. 2008 May;47(5):1544-56.
  3. Spee B, Carpino G, Schotanus BA, Katoonizadeh A, Vander Borght S, Gaudio E, Roskams T. Characterisation of the activated liver progenitor cell niche, potential involvement of Wnt and Notch signalling.  Gut. 2010 Feb;59(2):247-57.
  4. Boulter L, Govaere O, Bird TG, Radulescu S, Ramachandran P, Pellicoro A, Ridgway RA, Soo Seo S, Spee B, Van Rooijen N, Sansom OJ, Iredale JP, Lowell S, Roskams T, J Forbes SJ. Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med. 2012 Mar 4;18(4):572-9
  5. Komuta M, Govaere O, Vandecaveye V, Akiba J, Van Steenbergen W, Verslype C, Pirenne J, Aerts R, Yano H, Nevens F, Topal B, Roskams T. Histological diversity in cholangiocellular carcinoma reflects the different cholangiocyte phenotypes. Hepatology. Hepatology. 2012 Jun;55(6):1876-88.
  6. Andersen JB, Spee B, Blechacz BR, Avital I, Komuta M, Barbour A, Conner EA, Gillen MC, Roskams T, Roberts LR, Factor VM, Thorgeirsson SS. Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors. Gastroenterology. 2012 Apr;142(4):1021-1031
  7. Govaere O, Komuta M, Berkers J, Spee B, Janssen C, de Luca F, Katoonizadeh A, Wouters J, van Kempen LC, Durnez A, Verslype C, De Kock J, Rogiers V, van Grunsven LA, Topal B, Pirenne J, Vankelecom H, Nevens F, van den Oord J, Pinzani M, Roskams T. Gut. 2014 Apr;63(4):674-85. doi: 10.1136/gutjnl-2012-304351. Epub 2013 Aug 19.
  8. Sigala B, McKee C, Soeda J, Pazienza V, Morgan M, Lin CI, Selden C, Vander Borght S, Mazzoccoli G, Roskams T, Vinciguerra M, Oben JA. Sympathetic nervous system catecholamines and neuropeptide Y neurotransmitters are upregulated in human NAFLD and modulate the fibrogenic function of hepatic stellate cells. PLoS One. 2013 Sep 3;8(9)
  9. Soeda J, Mouralidarane A, Ray S, Novelli M, Thomas S, Roskams T, Diehl AM, Oben JA. The β-adrenoceptor agonist isoproterenol rescues acetaminophen-injured livers through increasing progenitor numbers by Wnt in mice. Hepatology. 2014 Sep;60(3):1023-34. Epub 2014 Jul 29.


Partner INT1 – QMUL (Centre for Tumour Biology) - to be updated

  1. Fellous TG, Islam S, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S, Mears L, Turnbull DM, Taylor RW, Greaves LC, Chinnery PF, Taylor G, McDonald SA, Wright NA, Alison MR. Locating the stem cell niche and tracing hepatocyte lineages in human liver. Hepatology. 2009 May;49(5):1655-63.
  2. Lin WR, Lim SN, McDonald SA, Graham T, Wright VL, Peplow CL, Humphries A, Kocher HM, Wright NA, Dhillon AP, Alison MR. The histogenesis of regenerative nodules in human liver cirrhosis. Hepatology. 2010 Mar;51(3):1017-26.
  3. Alison M.R. and Lin W.R. (2011) Hepatocyte turnover and regeneration: virtually a virtuoso performance. Hepatology 53:1393-1396.
  4. Kallis Y.N., Robson A.J., Fallowfield J.A., Thomas H.C., Alison M.R., Wright N.A., Goldin R.D., Iredale J.P. and Forbes S.J. (2011) Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response. Gut 60: 525-533.
  5. Alison MR, Marongiu F, Laconi E. Transplanted hepatocytes: wiped out or washed out? J Hepatol. 2012 Apr;56(4):996-7.
  6. Lin WR, Inatomi O, Lee CY, Kallis YN, Otto WR, Jeffery R, Poulsom R, Alison MR. Bone marrow-derived cells contribute to cerulein-induced pancreatic fibrosis in the mouse. Int J Exp Pathol. 2012 Apr;93(2):130-8.
  7. Alison MR, Lin WR, Lim SM, Nicholson LJ. Cancer stem cells: in the line of fire. Cancer Treat Rev. 2012 Oct;38(6):589-98.
  8. Alison MR, Lin WR (2013) . Liver cancer: Intrahepatic cholangiocarcinoma - appearances can be deceiving. Nat Rev Gastroenterol Hepatol vol. 10, (3) 131-133.
  9. Forbes SJ, Alison MR. Regenerative medicine. Knocking on the door to successful hepatocyte transplantation. Nat Rev Gastroenterol Hepatol. 2014 May;11(5):277-8. Epub 2014 Mar 25.


Partner INT2 – UKA (Med.Klinikum III ) - to be updated

  1. Streetz KL, Doyonnas R, Grimm D, Jenkins DD, Fuess S, Perryman S, Lin J, Trautwein C, Shizuru J, Blau H, Sylvester KG, Kay MA. Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells. Hepatology. 2008 Feb;47(2):706-18.
  2. Bettermann K., Vucur M., Haybaeck J., Koppe C., Janssen J., Heymann F., Weber A., Weiskirchen R., Liedtke C., Gassler N., Müller M., de Vos R., Wolf M.J., Boege Y., Seleznik G.M., Zeller N., Erny D., Fuchs T., Zoller S., Cairo S., Buendia M.A., Prinz M., Akira S., Tacke F., Heikenwalder M., Trautwein C. and Luedde T. (2010) TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell 17: 481-96.
  3. Kaldenbach M, Giebeler A, Tschaharganeh DF, Erschfeld S, Wasmuth HE, Dollé L, Floege J, Trautwein C, Streetz KL. HGF/c-Met signaling is important for the selection of transplanted hepatocytes. Gut. 2012 Aug;61(8):1209-18. Epub 2012 Jan 27.
  4. Liedtke C., Bangen J.M., Freimuth J., Beraza N., Lambertz D., Cubero F.J., Hatting M., Karlmark K.R., Streetz K.L., Krombach G.A., Tacke F., Gassler N., Riethmacher D. and Trautwein C. Absence of Caspase-8 protects from inflammation-related hepatocarcinogenesis in mice but triggers non-apoptotic liver injury. Gastroenterology. 2011 Dec;141(6):2176-87. doi: 10.1053/j.gastro.2011.08.037. Epub 2011 Aug 28.
  5. Freimuth J, Bangen JM, Lambertz D, Hu W, Nevzorova YA, Sonntag R, Gassler N, Riethmacher D, Trautwein C, Liedtke C. Loss of caspase-8 in hepatocytes accelerates the onset of liver regeneration in mice through premature nuclear factor kappa B activation. Hepatology. 2013 Nov;58(5):1779-89. doi: 10.1002/hep.26538. Epub 2013 Aug 6.
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