Vrije Universiteit Brussel

 

 

The "BRUSTEM" project (2008-2011 - ext. 2011-2014)

Regenerative medicine of the liver using synergistic mixtures of immature or mature human hepatocytes with mesenchymal stem/progenitor cells or with hepatic stellate cells

Promotors 2008-2011

Partner 1: PEDI, UCL - Prof. Etienne Sokal, UCL (Coordinator)
Partner 2: Gastroenterology (GAEN), UCL - Prof. Isabelle leclercq, UCL
Partner 3: Laboratory of Experimental Surgery, Prof. Pierre Gianello, UCL
Partner 4: Cell Biology (CYTO-LIVR), VUB - Prof. Albert Geerts / Prof. Leo A. van Grunsven
Partner 5: Toxicology (FAFY), VUB - Prof. Vera Rogiers
Partner 6: Experimental Gastroenterology - Prof. Jacques Devière, ULB
Partner 7: Cellular and Molecular Therapy Unit (UTCM) - Prof. Michel Toungouz, ULB
Partner 8: Laboratory for Research in Human Reproduction - Prof. Fabienne Devreker, ULB

Promotors 2011-2014

Partner 1: PEDI, UCL - Prof. Etienne Sokal, UCL (Coordinator)
Partner 2: Gastroenterology (GAEN), UCL - Prof. Isabelle leclercq, UCL
Partner 3: Liver Cell Biology & Toxicology (CYTO-LIVR & FAFY), VUB - Prof. Leo A. van Grunsven & Prof. Vera Rogiers
Partner 4: Cellular and Molecular Therapy Unit (UTCM) - Prof. Michel Toungouz, ULB

Funding : INNOVIRIS (prev. ISRIB) - Brussels Capital Region


The aim of the project is to explore alternative cell candidates for liver regenerative medicine. Mesenchymal stem/progenitor cells from intra and extrahepatic sources are specifically studied with respect to their proliferation and hepatogenic differentiation potential. In parallel, the selected cells will be investigated regarding their possible use as an in vitro cell model for toxico-pharmacological screening tests. Liver stellate cells will also be studied and developed for screening of anti-fibrogenic drugs. The final objective of this project is to provide standard operation procedures for a technology transfer to GMP compliant processes and translational clinical use of these hepatocyte-derived stem cells.

 



Back to top

©2004-2012• CYTO • Vrije Universiteit Brussel • Faculteit Geneeskunde & Farmacie • Laarbeeklaan 103 • 1090 Jette • Tel.: 02/477.44.09• jmlazou@vub.ac.be